PKM2 inhibitor 1
PKM2 inhibitor；PKM2-IN-1
CAS: 94164-88-2
Molecular Formula: C18H19NO2S2
PKM2 inhibitor 1 - Names and Identifiers
PKM2 inhibitor 1 - Physico-chemical Properties
| Molecular Formula | C18H19NO2S2 |
| Molar Mass | 345.48 |
| Density | 1.302±0.06 g/cm3(Predicted) |
| Boling Point | 496.5±55.0 °C(Predicted) |
| Solubility | DMSO : 5.56 mg/mL (16.09 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) |
| pKa | 0.81±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | PKM2-IN-1 is a pyruvate kinase M2 (PKM2) inhibitor with an IC 50 of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC 50 values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively. |
PKM2 inhibitor 1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.895 ml | 14.473 ml | 28.945 ml |
| 5 mM | 0.579 ml | 2.895 ml | 5.789 ml |
| 10 mM | 0.289 ml | 1.447 ml | 2.895 ml |
| 5 mM | 0.058 ml | 0.289 ml | 0.579 ml |
Last Update：2024-01-02 23:10:35
PKM2 inhibitor 1 - Introduction
PKM2 inhibitor;PKM2-IN-1, I .e. 3K compounds, is a chemical substance. The following is a description of its nature, use, preparation and safety information:
1. Nature:
- PKM2 inhibitor;PKM2-IN-1 is a solid substance.
-It has a specific chemical structure and composition.
-It may have specific physical properties, such as density, melting point, etc.
2. Use:
- PKM2 inhibitor;PKM2-IN-1 can be used as a catalyst for certain chemical reactions.
-It may have other specific applications, such as materials synthesis, electronic device manufacturing, etc.
3. Preparation method:
-Preparation of PKM2 inhibitor; The specific method of PKM2-IN-1 depends on its chemical structure and composition.
-Generally speaking, the preparation of compounds usually requires chemical reactions of appropriate raw materials under specific conditions.
-The process of preparation may involve specific reaction conditions, catalysts, solvents, etc.
4. Safety Information:
-When using PKM2 inhibitor;PKM2-IN-1, you must pay attention to personal protection and follow laboratory safety rules and operating guidelines.
-It may be potentially dangerous to humans and the environment.
-The compound needs to be stored and handled properly to avoid reaction with other chemicals or accidents.
-in the use and handling process, should pay attention to fire, explosion, ventilation and other aspects of safety requirements.
1. Nature:
- PKM2 inhibitor;PKM2-IN-1 is a solid substance.
-It has a specific chemical structure and composition.
-It may have specific physical properties, such as density, melting point, etc.
2. Use:
- PKM2 inhibitor;PKM2-IN-1 can be used as a catalyst for certain chemical reactions.
-It may have other specific applications, such as materials synthesis, electronic device manufacturing, etc.
3. Preparation method:
-Preparation of PKM2 inhibitor; The specific method of PKM2-IN-1 depends on its chemical structure and composition.
-Generally speaking, the preparation of compounds usually requires chemical reactions of appropriate raw materials under specific conditions.
-The process of preparation may involve specific reaction conditions, catalysts, solvents, etc.
4. Safety Information:
-When using PKM2 inhibitor;PKM2-IN-1, you must pay attention to personal protection and follow laboratory safety rules and operating guidelines.
-It may be potentially dangerous to humans and the environment.
-The compound needs to be stored and handled properly to avoid reaction with other chemicals or accidents.
-in the use and handling process, should pay attention to fire, explosion, ventilation and other aspects of safety requirements.
Last Update：2024-04-09 01:59:58
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QQ: 3008007409
Featured ProductsSpot supply
Product Name: PKM2 inhibitor(compound 3k) Visit Supplier Webpage Request for quotationCAS: 94164-88-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: PKM2-IN-1 Visit Supplier Webpage Request for quotationCAS: 94164-88-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: PKM2 inhibitor(compound 3k) Visit Supplier Webpage Request for quotationCAS: 94164-88-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: PKM2 inhibitor；PKM2-IN-1 Visit Supplier Webpage Request for quotation
CAS: 94164-88-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 94164-88-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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